ObjectiveTo investigate the distribution of age and gender as well as the change of serum uric acid level in different TOAST subtype of patients with acute cerebral infarction, providing reference for the effective treatment and prevention of the disease. MethodsA total of 158 patients with acute cerebral infarction were enrolled and classified according to TOAST criteria. Another 158 patients without cerebral blood vessel disease were selected as the control group. The serum uric acid levels of all cases were detected. The age and gender distribution as well as the serum uric acid levels of the patients with acute cerebral infarction classified by TOAST criteria were analyzed. ResultsOf all the 158 patients with acute cerebral infarction, there were 40 cases(25.3%)with large-artery atherosclerosis (LAA), 19 cases(12.0 %) with cardioembolism, 73 cases with small-artery occlusion (SAO), 16 cases(10.1%) with other clear causes, and 10 cases(6.3%) with unknown causes. The serum uric acid levels of large-artery atherosclerosis group and small-artery occlusion group were significantly higher than those of the control group. Compared with the control group, there were no significant difference in the serum uric acid levels of clear causes and unknown causes group (P＞0.05). Among different TOAST criteria, there were significant differences in smoking history and in hypertension, diabetes, hyperlipidemia and other complications (P＜0.05). ConclusionsPatients with acute cerebral infarction classified by TOAST criteria have different serum uric acid levels. The serum uric acid levels of LAA and SAO group are higher than those of other groups, which may be related to smoking history, diabetes, hypertension and other complicated diseases. It should be taken into consideration in clinical treatment.

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