ObjectiveTo understand the hepatitis B virus (HBV) infection status and its influencing factors in children aged 1-14 years in Guangxi. MethodsChildren aged 1-14 years were selected as survey subjects (5 895 children in total) from the database of hepatitis B seroepidemiological survey among 1- to 59-year-old population in Guangxi, 2018, and their HBV infection status and influencing factors were analyzed. ResultsThe positive rates of HBV surface antigen (HBsAg), HBV surface antibody (HBsAb), and HBV core antibody (HBcAb) and the HBV infection rate in children aged 1-14 years in Guangxi were 0.53%, 58.81%, 1.92%, and 2.07%, respectively. There was no statistically significant difference in the HBsAg positive rate among children in different age groups (P＞0.05), but there were statistically significant differences in the HBsAb and HBcAb positive rates and the HBV infection rate among children in different age groups (all P＜0.05). There were statistically significant differences in the HBsAg, HBsAb, and HBcAb positive rates and the HBV infection rate among children from some regions (all P＜0.05). The hepatitis B vaccination rate of children aged 1-14 years in Guangxi was 95.35%, of which the all doses administered rate and timely first dose administered rate of hepatitis B vaccine in children aged 1-4 years were 99.11% and 90.64%, respectively. Increasing age, maternal HBsAg positivity, tooth extraction, and not being born in hospitals at or above the county level were independent risk factors for HBV infection in children aged 1-14 years in Guangxi (all P＜0.05). ConclusionThe implementation of hepatitis B vaccine immunization strategy has achieved remarkable results in the prevention and control of hepatitis B in children in Guangxi. Hepatitis B vaccination should be strengthened for eligible children, and hepatitis B mother-to-child blocking intervention should be carried out to control iatrogenic infection, thus to reduce the risk of HBV transmission.

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