ObjectiveTo explore the serum 25-hydroxy-vitamin D3 level and its correlation with immune function in children with recurrent respiratory tract infection in Nanning. MethodsA total of 348 children with recurrent respiratory tract infection diagnosed and treated by Maternity and Child Health Hospital of Guangxi Zhuang Autonomous Region were selected as the disease group, and 126 healthy children who underwent physical examination at the same period were selected as the control group. Serum 25-hydroxy-vitamin D3 and immune function indexes levels were compared between the two groups. ResultsThe deficiency rate of 25-hydroxy-vitamin D3 in the disease group was higher than that in the control group, while the serum 25-hydroxy-vitamin D3 level, peripheral blood CD3+ and CD4+ level, the CD4+/CD8+ ratio, as well as serum IgA, IgG and IgM levels were all lower than those in the control group (all P＜0.05). There was no statistically significant difference in the peripheral blood CD8+ level between the two groups (P＞0.05). The peripheral blood CD3+ and CD4+ level, the CD4+/CD8+ ratio, and serum IgA, IgG, and IgM levels in children with 25-hydroxy-vitamin D3 deficiency in the disease group were lower than those in children with normal 25-hydroxy-vitamin D3 level (all P＜0.05). The serum 25-hydroxy-vitamin D3 level was positively correlated with the peripheral blood CD3+ and CD4+ and serum IgA and IgG levels in children in the disease group. ConclusionThe level of serum 25-hydroxy-vitamin D3 in children with recurrent respiratory tract infection in Nanning is low, and serum 25-hydroxy-vitamin D3 level of children had correlation with immune function.

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