内科

目的研究盐酸氟桂利嗪联合盐酸倍他司汀治疗对椎-基底动脉供血不足性眩晕症（VBIV）患者椎-基底动脉血流动力学、脑干听觉诱发电位和氧化应激的影响。方法选取2019年6月至2021年6月河南省中牟县人民医院神经内科收治的VBIV患者107例作为研究对象，采用随机数字表法将其分为对照组（n=53）和观察组（n=54）。对照组患者行盐酸氟桂利嗪治疗，观察组患者在对照组的基础上加用盐酸倍他司汀治疗，两组患者均连续治疗4周。比较两组患者治疗前后椎-基底动脉血流动力学、脑干听觉诱发电位检查结果和氧化应激指标水平，以及治疗期间的短暂性脑缺血发作（TIA）发生情况。结果治疗4周后，观察组患者的左侧椎动脉血流速度、右侧椎动脉血流速度、基底动脉血流速度均高于对照组，脑干听觉诱发电位波Ⅰ、Ⅲ、Ⅴ的潜伏期与波Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ的峰间期均短于对照组，血清超氧化物歧化酶水平高于对照组，血清丙二醛水平低于对照组（均P＜0.05）。治疗期间，观察组患者的TIA发生率低于对照组（P＜0.05）。结论盐酸氟桂利嗪联合盐酸倍他司汀治疗VBIV患者效果显著，能够改善椎-基底动脉血流动力学和脑干听觉诱发电位，减轻氧化应激反应，减少TIA发生，值得临床推广应用。

ObjectiveTo study the effects of flunarizine hydrochloride combined with betahistine hydrochloride on vertebro-basilar artery hemodynamics, brainstem auditory evoked potentials, and oxidative stress in patients with vertebro-basilar insufficiency vertigo (VBIV). MethodsA total of 107 VBIV patients who were admitted to the department of neurology of People′s Hospital of Zhongmu, Henan Province, from June 2019 to June 2021 were selected as the research objects, and they were divided into a control group (n=53) and an observation group (n=54) by the random number table method. Patients in the control group were treated with flunarizine hydrochloride, based on which patients in the observation group were treated with betahistine hydrochloride additionally. Both groups received continuous treatment for 4 weeks. The vertebro-basilar artery hemodynamics, brainstem auditory evoked potentials examination results, and oxidative stress indexes levels before and after treatment, and the incidence of transient ischemic attack (TIA) during treatment were compared between the two groups. ResultsAfter 4 weeks of treatment, the left vertebral artery flow velocity, right vertebral artery flow velocity and basilar artery flow velocity of the patients in the observation group were all higher than those in the control group, the latent periods of brainstem auditory evoked potentials waves Ⅰ, Ⅲ, Ⅴ and the interpeak intervals of waves Ⅰ-Ⅲ, Ⅲ-Ⅴ, Ⅰ-Ⅴ were all shorter than those in the control group, the serum superoxide dismutase level was higher than that in the control group, and the serum malondialdehyde level was lower than that in the control group (all P＜0.05). During treatment, the incidence of TIA in the observation group was lower than that in the control group (P＜0.05). ConclusionFlunarizine hydrochloride combined with betahistine hydrochloride has a significant effect in the treatment of VBIV patients, which can improve vertebro-basilar artery hemodynamics and brainstem auditory evoked potentials, reduce oxidative stress and the incidence of TIA, and is worthy of clinical application.