ObjectiveTo investigate the clinical effect of glucocorticoid combined with bronchofiberscopic alveolar lavage in the treatment of children with lobar pneumonia and its effects on their inflammatory factors and pulmonary function. MethodsA total of 66 children with lobar pneumonia were randomly divided into study group (36 cases) and control group (30 cases). The children in the control group were given routine glucocorticoid therapy, while the children in the study group were treated with glucocorticoid combined with bronchofiberscopic alveolar lavage. The total effective rate of clinical treatment and the levels of serum interleukin-6 (IL-6), C-reactive protein, forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF) before and after treatment were compared between the two groups. ResultsAfter 10 days of treatment, the total effective rate of treatment of children in the study group (94.44%) was higher than that in the control group (73.33%) (P＜0.05). Before treatment, there were no statistically significant differences in serum IL-6 and C-reactive protein levels between the two groups (all P＞0.05). After 10 days of treatment, the serum IL-6 and C-reactive protein levels in the study group were lower than those in the control group (all P＜0.05). Before treatment, there were no statistically significant differences in the levels of FVC, FEV1 and PEF between the two groups (all P＞0.05). After 10 days of treatment, the levels of FVC, FEV1 and PEF in the study group were higher than those in the control group (all P＞0.05). ConclusionGlucocorticoid combined with bronchofiberscopic alveolar lavage in the treatment of children with lobar pneumonia can effectively improve the clinical therapeutic effect and their serum inflammatory factor levels and pulmonary function.

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