ObjectiveTo observe the effect of computerized cognitive remediation therapy (CCRT) combined with drug therapy on psychological reasoning ability, visual spatial working memory ability and cognitive function in patients with schizophrenia during convalescence. MethodsTotally 92 schizophrenic convalescent patients hospitalized and treated in our hospital were selected between February 2018 and February 2020, and they were divided into observation group and control group according to the random number method, with 46 cases in each group. The control group was given conventional rehabilitation treatment combined with antipsychotics, and the observation group was additionally given CCRT intervention on the basis of the control group. The psychological reasoning ability, visual spatial working memory ability and cognitive function of the two groups were compared before and 6 weeks after intervention. ResultsBefore intervention, comparison of the patients′ faux pas, comic strips and metaphor scores showed no statistically significant differences between the two groups (P＜0.05). After 6 weeks of intervention, patients in both groups were significantly better in their faux pas, comic strips and metaphor scores, and the scores of patients in the observation group were significantly higher than those of the control group, with statistically significant differences (P＜0.05). Before intervention, there were no statistically significant differences in the number of between-group errors, overall mean reaction time, or strategy scores between the two groups (P＜0.05). After 6 weeks of intervention, the indicators mentioned above were significantly reduced (shortened, decreased) in both groups. The number of between-group errors was less in the observation group than that in the control group, and the overall mean reaction time was shorter and the strategy score was lower than those in the control group, with statistically significant differences (P＜0.05). Before intervention, no statistically significant difference was found in the scores of all dimension indicators of Matrics Consensus Cognitive Battery (MCCB) between the two groups (P＜0.05). After 6 weeks of intervention, the MCCB scores of both groups significantly increased (P＜0.05). The scores of spatial span test and semantic fluency test in the observation group were remarkably higher than those in the control group, and the differences were statistically significant (P＜0.05). ConclusionCCRT combined with antipsychotics can effectively improve the psychological states and enhance the spatial memory ability and cognitive function of schizophrenia patients during convalescence.

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