ObjectiveTo explore the relationship between blood uric acid, blood lipid levels and the distribution of intestinal flora in elderly patients with coronary heart disease. MethodA total of 120 elderly patients with coronary heart disease admitted to our hospital from March 2018 to August 2019 were selected as the study group, and 120 healthy volunteers who underwent physical examination in our hospital in the same period were selected as the control group. The levels of serum uric acid, blood lipid and the distribution of intestinal flora were measured and compared between the two groups. Pearson correlation analysis was performed on the relationship between the levels of blood uric acid, blood lipid and the number of intestinal flora in elderly patients with coronary heart disease. ResultsThe patients in the study group obtained higher levels of blood uric acid (BUA), total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C), whereas a lower level of high density lipoprotein cholesterol (HDL-C) as compared with the healthy volunteers in the control group, with statistically significant differences (P ＜0.05). The excrement from the patients in the study group yielded less number of Bifidobacteria, Lactobacillus and Bacteroides, whereas more number of Escherichia coli, Clostridium and Streptococcus in comparison with the excrement from the healthy volunteers in the control group, with statistically significant differences (P＜0.05). Pearson correlation analysis results showed that the level of BUA was negatively correlated with the number of Bifidobacteria and Lactobacillus in the excrement from the study group, and positively correlated with the number of Escherichia coli. The TG level of patients was positively correlated with the number of Escherichia coli and Clostridium in the excrement from the study group, and negatively correlated with the number of Bifidobacteria, Lactobacillus and Bacteroides. The level of HDL-C was positively correlated with the number of Clostridium and Streptococcus in the excrement from the study group. The level of LDL-C was negatively correlated with the number of Bifidobacteria, Clostridium and Streptococcus in the excrement from the study group. The TC level of patients was positively correlated with the number of Escherichia coli, and negatively correlated with the number of Bifidobacteria and Lactobacillus in the excrement from the study group. ConclusionThe increase of blood lipid and uric acid levels in elderly patients with coronary heart disease is related to the abnormal distribution of intestinal flora, which may have an important influence on the blood lipid level of patients.

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