内科

目的探讨生活方式干预联合益生菌治疗对青少年非酒精性脂肪肝患者血脂代谢及肝功能的影响。方法选取2019年3月至2020年3月我院收治的青少年非酒精性脂肪肝患者98例，采用抛硬币方式分为对照组（50例）和观察组（48例）。对照组患者在常规治疗基础上进行生活方式干预，观察组患者在对照组患者干预的基础上给予益生菌治疗，两组均干预治疗8周。比较两组患者的临床疗效；比较两组患者治疗前后的血脂水平及肝功能。结果治疗8周后，观察组患者的治疗总有效率（95.8%）显著高于对照组（82.0%），差异有统计学意义（P＜0.05）。治疗前，两组患者的血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平比较，差异无统计学意义（P＞0.05）。治疗8周后，两组患者的血清TC、TG、LDL-C水平均降低，观察组患者的水平显著低于对照组；两组患者的血清HDL-C水平均升高，观察组患者的水平显著高于对照组，差异有统计学意义（P＜0.05）。治疗前，两组患者的丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰转肽酶（γ-GT）水平比较，差异无统计学意义（P＞0.05）。治疗8周后，两组患者的ALT、AST、γ-GT水平均显著降低，观察组患者的水平显著低于对照组，差异有统计学意义（P＜0.05）。结论在常规治疗的基础上，生活方式干预联合益生菌治疗青少年非酒精性脂肪肝的临床疗效显著，可有效改善患者的血脂代谢状况及肝功能。

ObjectiveTo explore the effects of lifestyle intervention combined with probiotics on blood lipid metabolism and liver function of adolescents with non-alcoholic fatty liver disease. MethodsA total of 98 adolescents with non-alcoholic fatty liver disease who were admitted to our hospital from March 2019 to March 2020 were selected, and they were divided into control group (50 cases) and observation group (48 cases) using a coin toss. Patients in the control group received lifestyle intervention on the basis of conventional treatment, based on which patients in the observation group were treated with probiotics. The therapeutic intervention was treated for 8 weeks in both groups. The clinical efficacy, pre- and post-treatment lipid levels and liver function were compared between the two groups. ResultsAfter 8 weeks of treatment, the total effective rate of the observation group (95.8%) was significantly higher than that of the control group (82.0%), with a statistically significant difference (P＜0.05). Before treatment, there were no statistically significant differences in serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels between the two groups (P＞0.05). After 8 weeks of treatment, patients in both groups obtained lower levels of serum TC, TG and LDL-C, whereas a higher level of HDL-C. Compared with the control group, the observation group yielded significantly lower levels of serum TC, TG and LDL-C, while a significantly higher level of HDL-C, with statistically significant differences (P＜0.05). Before treatment, there were no statistically significant differences in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (γ-GT) between the two groups (P＞0.05). After 8 weeks of treatment, the levels mentioned above significantly decreased, and the levels of the observation group were significantly lower than those of the control group, with statistically significant differences (P＜0.05). ConclusionOn the basis of conventional treatment, lifestyle intervention combined with probiotics has significant clinical efficacy in the treatment of adolescents with non-alcoholic fatty liver disease, which can effectively improve the lipid metabolism and liver function in patients.