ObjectiveThrough data mining on the tumor chip database (Oncomine), survival analysis database (Kaplan-Meier Plotter) and protein-protein interaction database (STRING), to explore the expression of interferon-stimulated gene 15 (ISG15) in primary liver cancer and its relationship with prognosis of patients. MethodsThe related researches on ISG15 expression in liver cancer were searched in the database of Oncomine, Kaplan-Meier Plotter and STRING, respectively, to explore the expression of ISG15 gene in liver cancer tissues and corresponding normal tissues, and to draw the survival curve of ISG15 expression and the overall survival time in liver cancer patients. The Network tree diagram of ISG15 interacting protein was constructed, and the functional enrichment on ISG15 and its related protein genes was analyzed. ResultsBy searching the Oncomine database, it was found that 5 studies showed high expression of ISG15 in liver cancer tissues (including cell lines), and 2 studies showed that the expression level of ISG15 in liver cancer tissues was significantly higher than that in normal liver tissues (P＜0.05). According to search and analyze the Kaplan-Meier Plotter database, it was found that among patients with viral hepatitis and alcoholic liver cancer, the overall survival time of patients with high expression of ISG15 was significantly shorter than that of patients with low expression of ISG15 (P＜0.05). By searching ISG15 gene-related proteins in the STRING database, it was found that there were 10 interacting proteins of the ISG15 gene. And the results of bioprocess enrichment analysis showed that the above-mentioned proteins were mainly enriched in the negative regulation pathways of virus defense and viral genome replication. ConclusionISG15 is highly expressed in liver cancer tissues, which is closely associated with the prognosis of patients with viral hepatitis and alcoholic liver cancer.

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