ObjectiveTo investigate the effect of leuprorelin on sex hormone levels, uterine and ovarian volumes in sexual precocity girls. MethodsA total of 160 cases of sexual precocity girls admitted to our hospital from December 2018 to January 2020 were selected as the research objects, and they were divided into control group and observation group according to the random number method, with 80 cases in each group. The control group was treated with megestrol acetate, whereas the observation group was administrated leuprorelin for treatment, for a three-month treatment course. The levels of sex hormones, uterine volumes, ovarian volumes, and follicle diameters before and after treatment were compared between the two groups. ResultsBefore treatment, there were no statistically significant differences in the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), and estradiol (E2) between the two groups (P＞0.05). After 3 months of treatment, the levels of LH, FSH, and E2 in the two groups significantly decreased, and the levels mentioned above in the observation group were significantly lower than those in the control group, with statistically significant differences (P＜0.05). Before treatment, there were no statistically significant differences in uterine volumes, ovarian volumes, and follicle diameters between the two groups (P＞0.05). After 3 months of treatment, the uterine volumes, ovarian volumes, and follicle diameters of the two groups significantly reduced, the volumes and diameters of the observation group were significantly smaller than those of the control group, with statistically significant differences (P＜0.05). ConclusionLeuprorelin can effectively inhibit the secretion of sex hormones in sexual precocity girls, delay the development of uterine and ovarian, and alleviate the condition of the girls.

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