ObjectiveTo investigate the relationship between thyroid function, blood lipid metabolism, and the onset of diabetic nephropathy in patients with type 2 diabetes. MethodsA total of 106 patients with type 2 diabetes treated in our hospital from August 2015 to August 2017 were selected as the research objects. The serum levels of free thyroxine, free triiodothyronine, and thyroid-stimulating hormone were detected in patients. Patients were divided into hypothyroidism group (24 cases) and normal thyroid function group (82 cases) according to the test results. The general status, blood lipid level, renal function, and onset of diabetic nephropathy were compared between the two groups. ResultsPatients in the hypothyroidism group obtained higher proportion of women and levels of antithyroid peroxidase antibody, total cholesterol, triacylglycerol, and low-density lipoprotein, whereas a lower glomerular filtration rate, but higher urine microalbumin content and morbidity of diabetic nephropathy (25% vs. 8.5%), as compared with those indicators in the normal thyroid function group, with statistically significant differences (P＜0.05). ConclusionHypothyroidism can lead to abnormal blood lipid metabolism and increase morbidity of diabetic nephropathy in patients with type 2 diabetes. Monitoring and intervening thyroid function in patients with type 2 diabetes may help to decrease the morbidity of diabetes nephropathy.

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