内科

目的探讨葛酮通络胶囊联合低频重复经颅磁刺激治疗腔隙性脑梗死后焦虑抑郁共病患者的临床效果。方法选取2017年8月至2019年6月本院收治的腔隙性脑梗死后焦虑抑郁共病患者76例为研究对象，采用随机数字法分为对照组和观察组，每组38例。在常规治疗的基础上，对照组患者给予低频重复经颅磁刺激治疗，观察组患者给予葛酮通络胶囊联合低频重复经颅磁刺激治疗，连续治疗12周。比较两组患者治疗前后的汉密尔顿焦虑量表（HAMA）评分、汉密尔顿抑郁量表（HAMD）评分、中医证候积分、美国国立卫生院神经功能缺损评分（NIHSS）、Barthel指数、血清脑源性神经营养因子（BNDF）水平；比较治疗期间两组患者的不良反应发生情况。结果治疗前，两组患者的HAMA评分、HAMD评分、中医证候积分、NIHSS评分、Barthel指数、BNDF水平比较差异无统计学意义（P＞0.05）；治疗12周后，观察组患者的HAMA评分、HAMD评分、中医证候积分、NIHSS评分显著低于对照组，Barthel指数、BNDF水平显著高于对照组，差异有统计学意义（P＜0.05）。治疗期间两组患者的不良反应发生率比较差异无统计学意义（P＞0.05）。结论葛酮通络胶囊联合低频重复经颅磁刺激治疗，能够有效改善腔隙性梗死后焦虑抑郁共病患者的情绪障碍，促进其神经功能恢复，提高其生活自理能力，治疗安全性高。

ObjectiveTo investigate the clinical effect of Getong Tongluo capsule combined with low-frequency repetitive transcranial magnetic stimulation for patients with anxiety and depression comorbidity after lacunar infarction. MethodsA total of 76 patients with anxiety and depression morbidity after lacunar infarction admitted to our hospital from August 2017 to June 2019 were selected as the research objects, and they were divided into control group and observation group by the random number method, with 38 cases in each group. Based on the conventional treatment, patients in the control group were given low-frequency repetitive transcranial magnetic stimulation treatment, whereas the observation group was given Getong Tongluo capsules combined with low-frequency repetitive transcranial magnetic stimulation treatment, for twelve-week continuous treatment. The Hamilton Anxiety Scale (HAMA) scores, Hamilton Depression Scale (HAMD) scores, traditional Chinese medicine syndrome scores, National Institutes of Health Stroke Scale (NIHSS) scores, Barthel index, Serum brain-derived neurotrophic factor (BNDF) levels were compared between the two groups before and after treatment. The occurrence of adverse reactions was also compared between the two groups during treatment. ResultsThere were no statistically significant differences in HAMA scores, HAMD scores, traditional Chinese medicine syndrome scores, NIHSS scores, Barthel index, and BNDF levels between the two groups before treatment (P＞0.05). After 12 weeks of treatment, the HAMA scores, HAMD scores, traditional Chinese medicine syndrome scores, and NIHSS scores of the observation group were significantly lower than those of the control group, whereas the Barthel index and BNDF levels were significantly higher than those of the control group, with statistically significant differences (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P＞0.05). ConclusionGetong Tongluo capsule combined with low-frequency repetitive transcranial magnetic stimulation treatment can effectively improve the emotional disorder of patients with anxiety and depression comorbidity after lacunar infarction, promote the recovery of neurological function, improve their life self-care ability, and thus it is highly safe for treatment.