ObjectiveTo investigate the expression levels of vascular endothelial growth factor (VEGF), serum S100B protein, serum soluble CD40 (sCD40) and their relationships with cognitive impairment in patients with Alzheimer′s disease (AD). MethodsA total of 90 AD patients treated in our hospital from March 2016 to May 2018 were selected as AD group, meanwhile, 90 objects underwent the physical examination in our hospital during the same periods were selected as control group. Serum VEGF level, S100B level, and sCD40 level of the two groups were detected and compared. The patients with AD were assessed with the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Pearson correlation analysis was performed on the relationship between the serum VEGF level, S100B level, sCD40 level and their MMSE score, MoCA score. ResultsThe levels of S100B and sCD40 in the AD group were significantly higher than those in physical examinators of the control group, whereas the VEGF level was significantly lower than that of the control group. The difference was statistically significant (P＜0.05). The average MMSE score of AD patients was (23.6±4.1), and the average MoCA score was (23.2±3.7). The MMSE and MoCA scores of AD patients were positively correlated with serum VEGF levels (P＜0.05), while they had a negative correlation with S100B protein level (P＜0.05). ConclusionIncidence of AD patients may be related to the decrease of the expression level of VEGF and the increase of the expression levels of S100B and sCD40. The detection of VEGF and S100B levels may be helpful to evaluate the condition of AD patients.

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