ObjectiveTo investigate the value of amplitude-integrated encephalogram (aEEG) in the diagnosis of neonates with early brain injury and prognosis in neonatal acute bilirubin encephalopathy (ABE). MethodsA total of 50 cases of neonates with ABE were selected as the study objects, performing aEEG monitoring and brain-stem auditory evoked potential (BAEP) examination on these neonates. The growth and development of children were followed up and observed, then the prognosis of neonates was recorded. Spearman′s rank correlation analysis was conducted to analyze the relationship between the results of aEEG monitoring and BAEP examination, and the relationship between the results of aEEG monitoring and prognosis on neonates with ABE. The receiver operating characteristic (ROC) curve, which in accordance with aEEG monitoring results was determined the severity of brain injury and prognosis in neonates with ABE, was drawn, then analyzing the severity of brain injury and value of prognosis in ABE neonates in terms of aEEG monitoring results. ResultsBackground activity of aEEG monitoring in ABE neonates (mild or severely abnormal) was positively correlated with BAEP examination results (mild, moderate or severely abnormal) (r=0.842), and sleep-wake cycle (SWC) of aEEG monitoring (mature, immature or no SWC) was positively correlated with BAEP examination results (mild, moderate or severely abnormal) (r=0.596). Background activity of aEEG monitoring in ABE neonates (mild or severely abnormal) was positively correlated with prognosis (normal development, stunting or death) (r=0.428), and SWC of aEEG monitoring (mature, immature or no SWC) was positively correlated with prognosis (normal development, stunting, or death) (r=0.565). The AUC of determining the severity of brain injury in neonates based on background activity of aEEG monitoring was 0.596, with the sensitivity 1.000 and the specificity 0.391. The AUC of determining the severity of brain injury in neonates based on SWC of aEEG monitoring was 0.861, with the sensitivity 0.950 and the specificity 0.735. The AUC of determining prognosis in neonates based on background activity of aEEG monitoring was 0.601, with the sensitivity 0.917 and the specificity 0.447. The AUC of determining prognosis in neonates based on SWC of aEEG monitoring was 0.640, with the sensitivity 0.917 and the specificity 0.574. ConclusionPerforming aEEG monitoring is helpful to comparatively accurately assess the severity of brain injury in ABE neonates according to background activity and SWC; however, it still has some limitations in determining the prognosis of ABE neonates based on aEEG monitoring results.

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