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激素替代疗法联合坤泰胶囊治疗对卵巢早衰患者血脂及性激素水平的影响
Effect of hormone replacement therapy combined with Kuntai capsule on blood lipid and sex hormone levels in patients with premature ovarian failure

内科 201914卷04期 页码:411-413

作者机构:东莞市常平医院妇产科,广东省东莞市523573

基金信息:

DOI:10.16121/j.cnki.cn45-1347/r.2019.04.08

  • 中文简介
  • 英文简介
  • 参考文献
目的探讨激素替代疗法联合坤泰胶囊治疗对卵巢早衰患者血脂及性激素水平的影响。方法将2016年4月至2018年5月本院收治的120例卵巢早衰患者采用随机数字表法分成观察组与对照组,每组60例。对照组患者采用激素替代疗法治疗,观察组患者在对照组治疗的基础上加用坤泰胶囊治疗,治疗4周为1个疗程,两组患者均连续治疗2个疗程。检测比较两组患者血脂及性激素水平变化情况。结果治疗前,两组患者总胆固醇(TC)、三酰甘油(TG)、促黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)水平比较差异无统计学意义(P>0.05)。治疗2个疗程后,两组患者的TC、TG水平均显著下降,观察组患者的TC、TG水平显著低于对照组,差异有统计学意义(P<0.05);两组患者的LH、FSH水平均显著下降,E2水平均显著升高,观察组患者的LH、FSH水平显著低于对照组,E2水平显著高于对照组,差异有统计学意义(P<0.05)。结论激素替代疗法联合坤泰胶囊治疗卵巢早衰患者,可有效改善患者的血脂及性激素水平,值得在临床推广应用。
ObjectiveTo investigate the effects of hormone replacement therapy combined with Kuntai capsule on blood lipid and sex hormone levels in patients with premature ovarian failure. Methods120 patients with premature ovarian failure admitted to our hospital from April 2016 to May 2018 were randomly divided into observation group and control group, with 60 cases in each group. The patients in the control group were treated with hormone replacement therapy, whereas the patients in the observation group were treated with Kuntai capsule on the basis of the treatment of the control group. Both groups were treated continuously for 2 courses, and 4 weeks as one course. The changes condition of blood lipid and sex hormone levels between the two groups were compared. ResultsThere was no statistically significant difference in the levels of total cholesterol (TC), triglyceride (TG), luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (E2) in the two groups before treatment (P>0.05). The levels of TC and TG in the two groups were significantly decreased, and the levels of TC and TG in the observation group were significantly lower than the control group after 2 courses of treatment, with statistically significant difference (P<0.05). The levels of LH and FSH in the two groups were significantly decreased, whereas the levels of E2 were prominently increased. Compared with the control group, the observation group had lower levels of LH and FSH, and higher levels of E2, with statistically significant difference (P<0.05). ConclusionHormone replacement therapy combined with Kuntai capsule in the treatment of patients with premature ovarian failure can effectively improve the blood lipid and sex hormone levels of patients, and it is worthy of clinical application.

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