ObjectiveTo explore effects of matrine injection combined with CIK cells adoptive immunotherapy on the tumor markers of patients with advanced lung cancer. MethodsA total of 39 patients with advanced lung cancer admitted from different hospitals in Baiyin area were enrolled and randomly divided into matrine group, with pure matrine injection treatment, CIK group, with pure CIK cells adoptive immunotherapy, and matrine plus CIK group, with matrine injection combined with CIK cells adoptive immunotherapy; each group contained 13 cases. After three-month treatment, the levels of tumor markers in alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) were detected and compared between the three groups. The incidence of accompanying symptoms as for nausea, vomiting, diarrhea, and fever during treatment between the three groups was compared. ResultsAfter 3 months of treatment, the levels of AFP, CEA, and CA199 in the three groups were in a descending order as: matrine group, CIK group and matrine plus CIK group, with statistically significant difference (P＜0.05). The incidence of accompanying symptoms as for nausea, vomiting, diarrhea, and fever during treatment in the matrine plus CIK group was lower than the matrine group and CIK group, with statistically significant difference (P＜0.05). ConclusionMatrine injection combined with CIK cells adoptive immunotherapy in the treatment of patients with advanced lung cancer can effectively reduce the levels of tumor markers, and adverse reactions are mild. It is suitable for tumor patients who cannot tolerate chemotherapy.

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