内科

目的探讨银杏叶提取物（EGb)治疗帕金森病（PD)的疗效及对患者TNF-α、IL-1β、IL-6水平的影响。方法选取在我院住院治疗的PD患者60例为研究对象，随机分为实验组和对照组，每组30例。对照组患者给予多巴丝肼治疗，实验组患者在对照组治疗基础上，加用银杏叶提取物治疗。比较两组患者的临床治疗效果；检测比较两组患者治疗前后的TNF-α、IL-1β和IL-6水平以及帕金森病评分量表（UPDRSⅠ、Ⅱ、Ⅲ部分）评分。结果治疗15 d后，实验组患者的治疗有效率（76.67%）显著高于对照组（53.33%），差异有统计学意义（P＜0.05）；两组患者的TNF-α、IL-1β和IL-6水平均显著下降，实验组患者的TNF-α、IL-1β和IL-6水平显著低于对照组，差异有统计学意义（P＜0.05）；两组患者的UPDRSⅠ、Ⅱ、Ⅲ部分评分均显著低于治疗前，实验组患者的UPDRSⅠ、Ⅱ、Ⅲ部分评分均显著低于对照组，差异有统计学意义（P＜0.05）。结论银杏叶提取物治疗能有效地降低PD患者TNF-α、IL-1β和IL-6水平，减轻患者炎症反应，提高临床疗效。

ObjectiveTo investigate the efficacy of Ginkgo biloba extract in treating Parkinson’s disease (PD) and its effects on levels of TNF-α,IL-6,IL-1β. MethodsA total of 60 cases of PD patients of our hospital were selected as research objects and randomly divided into experimental group and control group,with 30 cases in each group.Patients in control group were treated with madopar,while patients in experimental group were added with Ginkgo biloba extract on the basis of treatment of control group.Compared with clinical efficacy between two groups,and the levels of TNF-α,IL-6,IL-1β and the scores of Unified Parkinson′s Disease Rating Scale (UPDRS I, II, III) before and after treatment. ResultsAfter 15 days treatment,efficiency of treatment in the experimental group was significantly higher than that in the control group,with statistical significance（P＜0.05）.The levels of TNF-α,IL-6,IL-1β were decreased in both groups,and those in the experimental group were lower than control group,with statistical significance (P＜0.05).The scores of UPDRS I,II,III in two groups were decreased after treatment,and those in experimental group were lower than control group, with statistical significance (P＜0.05). ConclusionGinkgo biloba extract proves obvious effects of reducing levels of TNF-α,IL-6,IL-1β in patients with PD,which is helpful to improve the clinical efficacy.