ObjectiveTo investigate the therapeutic efficacy of Yangxue Qing Nao granule combined with alteplase on acute cerebral infarction and its influence on inflammatory factors and coagulation function. MethodsA total of 98 patients with acute cerebral infarction admitted to our hospital from January 2016 to September 2017 were selected as the subjects. According to the random table method, they were divided into observation group and control group,with 49 cases in each group. The control group was treated with thrombolytic therapy with alteplase, and the observation group was combined with Yangxue Qing Nao granule on the basis of the control group. The curative effect of the two groups was compared, and the changes of NIHSS score, Barthel index score, inflammatory factors and coagulation function were compared before and after treatment between the two groups. ResultsThe total effective rate of the observation group (91.84%) was higher than that of the control group (73.47%),with statistical significance (P＜0.05).After treatment, the NIHSS score was decreased in both groups,and that in observation group was lower than control group, with statistical significance (P＜0.05). The Barthel index score increased in both groups,and that in the observation group was higher than the control group (P＜0.05).The serum IL-1β, CRP, IL-6 and TNF-α levels in the observation group were all decreased,which were lower than the control group (P＜0.05).PT and APTT levels was increased and Fib was decreased in two groups,while PT and APTT levels in observation group were higher than that of control group,level of Fib was lower than that of control group,with statistical significance (P＜0.05). ConclusionYangxue Qing Nao Granules combined with alteplase proves obvious effects in the treatment of acute cerebral infarction by mitigating the inflammatory reaction and improving coagulation function.

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