ObjectiveTo investigate the effect of different time window decompression on patients with acute cerebral infarction (ACI) and factors affecting prognosis. Methods135 cases of acute ischemic stroke complicated with essential hypertension were selected. They were randomly divided into group A and group B. In group A, 66 patients were treated with antihypertensive therapy from 1 to 3d after onset. In group B, 69 patients were treated with antihypertensive therapy from 4 to 7d after onset. The clinical effects of 30d, 90d and 180d were compared between the two groups after stroke. Follow up for 6 months, compared two groups of patients with no event survival rate and adverse events (complications, recurrence of cerebral infarction, mortality) incidence. Multivariate Logistic regression analysis was performed to identify the factors influencing the prognosis of patients. ResultsThe total effective rates of group A and group B were 85.51% and 68.18% respectively, and the difference between the two groups was statistically significant (P＜0.05). After 6 months of follow-up, the event free survival rate in group B (81.16%) was significantly higher than that in group A (63.64%), and the difference was statistically significant (P＜0.05). The incidence of adverse events in group B (18.84%) was significantly lower than that in group A (36.36%), and the difference was statistically significant (P＜0.05). The result of factor Logistic regression analysis showed that, lesion diameter, NIHSS score and blood pressure lowering time were independent prognostic factors for ACI patients (P＜0.05). ConclusionThe time of antihypertensive treatment is an important factor affecting the prognosis of ACI patients. After 4-7 d of ACI, the patients are treated with antihypertensive therapy, which is beneficial to the recovery of neurologic function and the improvement of prognosis.

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