ObjectiveTo test the levels of serum vitamin D and glycosylated hemoglobin (HbA1c) in gestational diabetes mellitus (GDM) women and healthy pregnant women, and to explore the relationship between these two factors. Methods200 GDM pregnant women (diabetes group) and 76 healthy pregnant women (control group) were selected from December 2016 to December 2017 in the department of Obstetrics and gynecology in Sichuan Santai People′s Hospital. The levels of vitamin D and HbA1c in two groups of pregnant women were detected, and the relationship between vitamin D content and HbA1c level in GDM pregnant women was analyzed. ResultsThe plasma 25-OH-D level in the DM group was significantly lower than that in the control group (P＜0.01). The proportion of vitamin D deficiency and vitamin D deficiency in the diabetic group was significantly higher than that of the control group, and the normal proportion of vitamin D was lower than that of the control group, the difference was statistically significant (P＜0.05). The levels of HbA1c in diabetic pregnant women were not related to their age (r=0.280, P=0.172), height (r=0.136, P=0.262), pre pregnancy weight (r=0.158, P=0.401), and pregnancy week (r=-0.246, P=0.074), and negative correlation with vitamin D content (r=-1.816, P=0.014). ConclusionThe content of vitamin D in serum in pregnant women with gestational diabetes is significantly lower than that of healthy pregnant women, and the content of vitamin D is closely related to the level of HbA1c. Early detection of vitamin D content can determine the risk of GDM in pregnant women.

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