ObjectiveTo investigate the effects of tanshinone II-A (TSII-A) on renal function and vancomycin concentration in blood and kidney tissues in SD rats damaged by vancomycin. Methods60 male SD rats were randomly divided into blank group, model group, TS II-A group with low dose, with medium and high dose, 12 rats in each group. A rat model of renal injury was established by intraperitoneal injection of VAN (200 mg/kg). Which in each group were intraperitoneally injected with different doses of TS II-A (blank group and model group intraperitoneal injection of normal saline) for 10d after successful modeling. The rat urine was taken to determine the α1 microglobulin (α1-MG), β2 microglobulin (β2-MG), albumin (ALB), transferrin (TRF), immunoglobulin G (IGG), urinary creatinine, urea, total protein / urinary creatinine (UTP/C). The blood and kidney tissues were taken to detect the endogenous creatinine clearance (Ccr), glomerular filtration rate (GFR), uric acid (SUA), total carbon dioxide (TCO2), N terminal precursor brain natriuretic peptide (NT-proBNP) and serum vancomycin concentration. ResultsCompared with the blank group, the levels of urine α1-MG, β2-MG, ALB, TRF, IGG, UTP/C and GFR and NT-proBNP in blood of model group increased significantly (P＜0.05). Urine BUN, Scr levels and blood Ccr were significantly decreased (P＜0.05). There was no significant difference in the levels of SUA and TCO2 in urine (P＞0.05). Compared with the model group, the levels of the urine α1-MG, β2-MG, ALB, TRF, IGG, UTP/C and the serum GFR and NT-proBNP levels in the urine of TSII-A rats were significantly decreased (P＜0.05). Urine BUN, Scr levels and blood Ccr increased significantly (P＜0.05). The decrease of serum vancomycin Valley concentration (P＜0.05). There was no significant difference in the levels of SUA and TCO2 in urine. ConclusionTS II-A can effectively improve the renal function of VAN injured rats and reduce the concentration of vancomycin in the serum and kidney tissues of rats.

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