内科

目的探讨雷贝拉唑联合磷酸铝凝胶治疗消化性溃疡患者的疗效及对血清TGF-a和Gas水平的影响。方法选取2014年1月至2017年1月潮州市中医医院消化内科收治的消化性溃疡患者98例，随机分为对照组和观察组各49例。对照组患者单用雷贝拉唑治疗，观察组患者在此基础上联合磷酸铝凝胶治疗，治疗4周后比较两组患者的临床疗效，比较治疗前后患者血清TGF-a和Gas水平改变情况以及不良反应发生情况。结果观察组患者的治疗总有效率为95.92%，对照组为83.67%，两组比较差异有统计学意义（P＜0.05）。治疗前两组患者血清Gas、TGF-a水平比较差异无统计学意义（P＞0.05）；治疗4周后，两组患者血清Gas水平显著降低、TGF-a水平显著升高（P＜0.05），观察组患者Gas水平显著低于对照组、TGF-a水平显著高于对照组，差异有统计学意义（P＜0.05）。观察组不良反应发生率（6.12%）显著低于对照组（20.41%），差异有统计学意义（P＜0.05）。结论与单用雷贝拉唑治疗比较，雷贝拉唑联合磷酸铝凝胶治疗消化性溃疡患者，能显著降低TGF-a水平，提高Gas水平，提高临床治疗效果，减少不良反应的发生。

ObjectiveTo investigate the effect of rabeprazole combined with Aluminium Phosphate Gel in the treatment of patients with peptic ulcer and its effect on the level of TGF-a and Gastrins. Methods98 patients with peptic ulcer admitted from January 2014 to January 2017 in Chaozhou traditional Chinese medicine hospital were randomly divided into two groups: the control group and the observation group, 49 cases each. The control group were treated with rabeprazole alone. On the basis of that, the observation group combined with Aluminium Phosphate Gel therapy. The clinical efficacy of two groups of patients was compared after 4 weeks treatment. The changes of serum TGF-a and Gastrins levels, the incidence of adverse reactions were compared before and after treatment. ResultsThe total effective rate of treatment was 95.92% in the observation group and 83.67% in the control group, the difference between the two groups was statistically significant (P＜0.05). There was no significant difference in serum Gastrins and TGF-a levels between the two groups before treatment (P＞0.05). After 4 weeks of treatment, the level of serum Gastrins in the two groups decreased and the level of TGF-a increased (P＜0.05). The level of Gastrins in the observation group was lower than that of the control group and the level of TGF-a was higher than that of the control group, and the difference was statistically significant (P＜0.05). The adverse reaction rate of the observation group (6.12%) was lower than that of the control group (20.41%), and the difference was statistically significant (P＜0.05). ConclusionCompared with the treatment with rabeprazole alone, the combination of Aluminium Phosphate Gel and Aluminium Phosphate Gel can significantly reduce the level of TGF-a, improve the level of Gastrins, improve the clinical effect and reduce the incidence of adverse reactions.