目的探讨莫西沙星或头孢哌酮钠他唑巴坦钠治疗泌尿生殖系统感染的临床效果。方法选取2012年 7月至2014年4月我院收治的泌尿生殖系统感染患者226例为研究对象,随机分为莫西沙星组和头孢哌酮钠他唑巴坦钠组,每组113例,分别给予莫西沙星和头孢哌酮钠他唑巴坦钠进行治疗1周,比较两组患者的临床疗效、病原体检出率与清除率以及不良反应发生率。结果莫西沙星组患者的治疗总有效率(92.9%)显著高于头孢哌酮钠他唑巴坦钠组(80.5%),临床疗效优于头孢哌酮钠他唑巴坦钠组(P<0.01)。两组患者的解脲支原体(Uu)与人型支原体(Mh)检出率和清除率比较,差异均无统计学意义(P>0.05)。莫西沙星组患者的不良反应发生率显著低于头孢哌酮钠他唑巴坦钠组(P<0.05)。结论莫西沙星治疗泌尿生殖系统感染患者的临床效果优于头孢哌酮钠他唑巴坦钠,患者的不良反应发生率更低,值得在临床推广应用。
ObjectiveTo investigate the clinical effect of moxifloxacin or cefoperazone sodium tazobactam sodium in the treatment of patients with genitourinary system infection. Methods226 cases of genitourinary system infection were selected in our hospital from July 2012 to April 2014. Who were randomly divided into the moxifloxacin group and the cefoperazone sodium tazobactam sodium group, 113 cases in each group. The treatment of moxifloxacin and cefoperazone sodium tazobactam sodium for 1 weeks, respectively. The clinical efficacy, pathogenic rate, clearance rate and the incidence of adverse reactions were compared between the two groups. ResultsThe total effective rate of treatment in the moxifloxacin group (92.9%) was higher than the cefoperazone sodium tazobactam sodium group (80.5%). The clinical effect is superior to cefoperazone the sodium tazobactam sodium group (P<0.01). There was no significant difference in the detection rate and clearance rate of Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh) in the two groups (P>0.05). The incidence of ADR in the moxifloxacin group was lower than that in the cefoperazone sodium tazobactam sodium group (P<0.05). ConclusionMoxifloxacin is better than cefoperazone sodium tazobactam sodium in the treatment of genitourinary infection patients. The incidence of adverse reactions in patients is lower, and it is worth popularizing in clinical application.