ObjectiveTo evaluate the situation of craniocerebral trauma operation patients with epilepsy seizures and the effect of sodium valproate prophylactic antiepileptic. Methods164 cases of craniocerebral trauma treated in our hospital from September 2014 to September 2016 were selected. Which were divided into the observation group and the control group, 82 cases in each group according to the random number table method. The observation group were treated with sodium valproate of preventive antiepileptic perioperative treatment, and the control group did not give preventive antiepileptic treatment. The incidence of epilepsy within 1 months after operation, the incidence of epilepsy in different types of patients, and the incidence of epilepsy in patients with different severity of trauma were observed. The incidence of epilepsy was compared between two groups within 1 months after the operation. ResultsThere were 32 cases of epileptic seizures found within 1 months after operation, and the incidence was 19.51%. The incidence of postoperative epilepsy in patients with closed brain trauma (5%) was lower than that of open brain trauma (42.2%), and the difference was statistically significant (P＜0.01). The incidence of postoperative epilepsy in patients with severe craniocerebral trauma (39.3%) was higher than that of patients with mild and moderate craniocerebral trauma (7.8%).The difference was statistically significant (P＜0.01). The incidence of epilepsy (1.2%) in the observation group was lower than that of the control group (37.8%) 1 months after operation, and the difference was statistically significant (P＜0.01). ConclusionThe incidence of epilepsy after craniocerebral trauma is high. Prophylactic antiepileptic perioperative treatment with valproate can significantly reduce the incidence of epilepsy and promote recovery of patients.

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