【Abstract】ObjectiveTo investigate the effect of intensitymodulated radiation therapy combined with oxaliplatin and capecitabine concurrent chemotherapy in the treatment of advanced esophageal cancer. MethodsA total of 56 patients with advanced esophageal cancer who were treated in our hospital from January 2012 to December 2013 were divided into two groups according to random number table, 28 in each group. The control group was treated with intensitymodulated radiation therapy. The study group received intensitymodulated radiation therapy combined with oxaliplatin and capecitabine concurrent chemotherapy. The treatment effect, longterm survival, QLQOES24 score and incidence of adverse reactions were compared between the two groups. ResultsAfter 6 weeks of treatment, the total effective rate of the study group (82.1%) was higher than that of the control group (57.1%), the difference was statistically significant (P＜0.05). The 1, 2, 3year survival rate of the study group was higher than that of the control group (P＜0.05). There was no significant difference in adverse reactions and INM clinical stages between the two groups (P＞0.05). There was no significant difference in QLQOES24 score between the two groups after 1 and 2 months of treatment(P＞0.05). The QLQOES24 score of the study group was significantly higher than that of the control group after 6 months of treatment(P＞0.05). ConclusionThe treatments of intensitymodulated radiation therapy combined with oxaliplatin and capecitabine concurrent chemotherapy can effectively improve the clinical treatment effect, improve the quality of life, increase little adverse reactions of patients with advanced esophageal cancer. It is worthy of promotion and application.

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