内科

目的探讨人类Ⅰ型3?-羟基类固醇脱氢酶（HSD3B1）基因多态性与壮族盐敏感高血压的关系。方法随机选取壮族盐敏感高血压患者与盐不敏感高血压患者各80例，记录并分析入选者病史、体格检查资料、实验室检查资料和超声心动图检查资料；提取入选者外周血DNA，应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测HSD3B1基因rs1047303的A/C多态性，比较不同组基因型和等位基因频率。结果与盐不敏感高血压患者比较，壮族盐敏感高血压患者存在较高的基础心率，较高的血压，较高的总胆固醇、三酰甘油和低密度脂蛋白水平(P＜0.05或P＜0.01)，但两组患者的体质指数和高密度脂蛋白水平比较差异没有统计学意义（P＞0.05）；两组患者HSD3B1基因rs1047303的A/C等位基因和基因型频率比较差异均无统计学意义(P＞0.05)。结论HSD3B1基因A/C多态性与壮族盐敏感高血压无显著关联，HSD3B1基因的rs1047303多态性不是壮族盐敏感高血压的危险因素。

ObjectiveTo determine the relationship between HSD3B1 gene polymorphisms and salt sensitive hypertension in Zhuang patients. MethodsA total of 160 participants were divided into salt sensitive hypertension group and non-salt sensitive hypertension group, with 80 cases in each group. The data of diseases history, physical examination, laboratory parameters and echocardiography were recorded and analyzed; the Peripheral blood DNA of all patients were extracted, the polymerase chain reaction-restriction fragment length polymorph (PCR-RFLP) technique was used to determined the polymorphisms of HSD3B1 gene rs1047303 A/C, the genotypes and allele frequency was compared between the two groups. ResultsThe levels of basic heart rate, blood pressure, total cholesterol, triglyceride and low density lipoprotein in salt sensitive hypertension group were significantly higher than those in non-salt sensitive hypertension group (P＜0.05 or P＜0.01), but no statistical significance was found between two groups in the level of body mass index and high-density lipoprotein (P＞0.05); there was no significant difference of both genotypes and A/C alleles frequency was found between the two groups (P＞0.05). ConclusionsThe A/C polymorphism of HSD3B1 gene is not associated with salt sensitive hypertension patients in Zhuang patients, rs1047303 A/C polymorphism of HSD3B1 gene is not the risk factor of salt sensitive hypertension in Zhuang patients.