内科

目的评价缬沙坦联合氢氯噻嗪治疗老年原发性高血压的疗效。方法选择老年原发性高血压患者100例，随机分为观察组和对照组，每组50例，观察组给予缬沙坦联合氢氯噻嗪治疗，对照组给予氢氯噻嗪治疗，比较两组患者治疗4周后的平均收缩压（SBP）、舒张压（DBP）水平，并对其疗效进行评价。结果治疗4周后，观察组患者的SBP为（117.23±12.65）mmHg，DBP为（80.12±4.86） mmHg，对照组患者SBP为（128.86±11.37）mmHg，DBP为（85.23±5.37）mmHg，均较治疗前显著降低，且观察组降低更明显，与对照组比较，差异具有统计学意义（P＜0.05）；治疗4周后，观察组患者治疗总有效率为96.00%，显著高于对照组的74.00%，组间比较差异具有统计学意义（P＜0.05）。结论缬沙坦与氢氯噻嗪联合治疗老年原发性高血压可以提高疗效，有效控制血压水平，且安全性好，值得推广和应用。

ObjectiveTo evaluate the effect of valsartan combined with hydrochlorothiazide in the treatment of elderly patients with primary hypertension. Methods100 elderly patients with essential hypertension were randomly divided into observation group and control group, each 50 cases, the observation group was given valsartan combined with hydrochlorothiazide,while the control group was treated with hydrochlorothiazide, the levels of average systolic blood pressure (SBP), diastolic blood pressure (DBP) and curative effect of the two groups were recorded and compared after treatment for 4 weeks. ResultsThe SBP and DBP of patients in both groups were decreased significantly after treatment (P＜0.05), the average level of SBP and DBP in observation group was (117.23±12.65) mmHg and (80.12±4.86)mmHg, respectively, which were both significantly lower than that in control group, (128.86±11.37)mmHg and (85.23±5.37) mmHg, respectively; the total efficiency of observation group was 96%, which was significantly higher than that of the control group(74%) (P＜0.05). ConclusionsThe application of valsartan combined with hydrochlorothiazide on senile patients with primary hypertension can enhance the clinical efficacy, effective control of blood pressure and safety, which should be popularized.