ObjectiveTo investigate the relationship between single nucleotide polymorphism(SNP) of TSPAN8(rs2270587) and susceptibility of hepatocellular carcinoma pedigrees in Fusui County of Guangxi. MethodsTwenty high incidence hepatocellular carcinoma(HCC) families (20 HCC cases and 59 immediate family members) and 10 health control families (40 cases) were selected from Fusui Country of Guangxi Zhuang Autonomous Region. Matrixassisted laser desorption/ionization-time of flight(MALDI-TOF) was used to detect genotyping of rs2270587 loci in TSPAN8 gene, the correlation between TSPAN8(rs2270587) polymorphism and susceptibility of HCC families was analyzed. Results(1) The TSPAN8 rs2270587 locus owned two alleles（C and T）and three genotypes(CC、CT and TT). (2)In the control group of normal families and non-HCC group of HCC families, HCC onset risks of individuals with rs2270587 locus CT genotype of ATF5 gene were 0.34 times （95%CI=0.07-1.59，P＞0.05）and 0.42 times（95%CI=0.11-1.66，P＞0.05）of individuals with CC genotype respectively; in the control group of normal families, HCC onset risks of individuals with rs2270587 locus T allele genotype was 0.29 times of individuals with C allele genotype (95%CI=0.09-0.92，P=0.028）, in non-HCC group of HCC families, HCC onset risks of individuals with rs2270587 locus T allele genotype was 0.46 times of individuals with C allele genotype (95%CI=0.15-1.42，P＞0.05）. ConclusionsThere could be correlation between polymorphism of TSPAN8(rs2270587) gene and genetic susceptibility of HCC in Fusui County of Guangxi, the T allele might be a protective factor of HCC.

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