ObjectiveTo investigate the influence of community psychological intervention based on five-element theory on neural function in patients with post-stroke depression (PSD). MethodsA total of 50 patients with PSD were randomly divided into observation group and control group, with 25 cases in each. Control group was treated with the conventional rehabilitation therapy and antidepressant treatment, while the observation group was given community psychological intervention based on five-element theory on the basis of control group. The treatment course of the two groups was 6 months, the scores of NIHSS, BI, MMSE, HAMD were compared between two groups. ResultsCompared with before intervention, the scores of NIHSS, BI, MMSE and HAMD in two groups were improved significantly after treatment，and the scores of these indices in the observation group were superior to those of control group(P＜0.05). ConclusionsFive elements syndrome differentiation psychological intervention on the basis of conventional rehabilitation therapy and antidepressant treatment can significantly improve the neural function in patients with post-stroke depression, and should be widely applied.

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