ObjectiveTo investigate the early diagnostic and the prognostic value of amplitude integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE). MethodsA total of 45 patients with hypoxic-ischemic encephalopathy(HIE) were selected and divided into mild HIE group (19 cases) , moderate HIE group (15 cases) and severe HIE group (11 cases) according to clinical diagnostic criteria, and 11 cases of healthy full-term newborns in our hospital at the same period were chosen as the control group. The aEGG features of all cases were observed, physical development situation and neuropsychological development scores were detected after 6 moths. ResultsThe aEGG of the control group were normal; the abnormal rates of aEGG in mild, moderate and severe hypoxic-ischemic encephalopathy group were 15.8%, 86.7% and 100.0%,respectively, and there was positive correlation between aEEG and HIE clinical indexing (r=0.632). After 6-month follow-up, head circumference, height, weight and MI, DQ in severe group were worse than those in the other three groups and there was significant difference in head circumference, MI, DQ among four groups(P＜0.05);while the differences of height, weight among four groups was not significant (P＞0.05). ConclusionsThe abnormality of aEGG is closely related to HIE clinical grading, and it can be used to evaluate the status of the brain function, and can assist in early diagnosis and predict prognosis of HIE.

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