目的探讨ABCD3评分结合头颈CT血管成像(CTA)预测短暂性脑缺血发作(TIA)后7 d内发生脑梗死的临床价值。方法收集136例TIA患者临床资料和CTA检查结果。按ABCD3评分法进行评分,分为低危(0~3分)、中危(4~5分)、高危(6~9分)三组;按CTA结果分为血管轻度(狭窄<50%)、中度(狭窄50%~69%)、重度(狭窄>70%)狭窄,观察TIA后7 d内脑梗死发生率。结果29例(21.3%)患者在TIA后7 d内发生脑梗死。低危组与中危组、高危组患者脑梗死发生率(分别为10.2%、22.5%、40.5%)比较差异有统计学意义(P<0.05)。中重度狭窄的颅内外动脉狭窄的患者TIA后7 d内脑梗死发生率显著高于轻度动脉狭窄的患者(χ2=27.827,P=0.000)。ABCD3评分≥4分、颅内外动脉狭窄≥50%组患者7 d内脑梗死发生率显著高于ABCD3评分<4分、颅内外动脉狭窄<50%组(P<0.001)。预测TIA 后7 d 内脑梗死风险时,ABCD3评分和颅内外动脉狭窄程度的AUC分别为0.752和0.779(P<0.001)。结论ABCD3评分法是预测TIA后7 d内发生脑梗死的有效方法,进一步结合头颈CTA检查能提高预测的准确性。
ObjectiveTo investigate the clinical value of ABCD3 score combined with CTA in identifying transient ischemic attack (TIA)patients with high risks of cerebral infarction within 7 days. MethodsThe clinical data and CTA findings of 136 patients with TIA were analyzed. Patients were divided into low-risk group (0-3 points), moderate-risk group(4-5 points), high-risk group(6-9 points)and vascular mild group(stenosis<50%), moderate stenosis group(stenosis 50%-69%), severe stenosis group (stenosis>70%)according to ABCD3 score and the results of CTA,respectively.The incidence of cerebral infarction was observed after TIA within 7 days. Results29 patients(21.3%) suffered cerebral infarction after TIA within 7 days. The incidence of cerebral infarction in low-risk group (10.2%) was significantly lower than that of medium-risk group (22.5%) and high-risk group (40.5%) (P<0.05). The incidence of cerebral infarction of artery moderate and severe stenosis group were significantly higher than that of mild stenosis group(χ2=27.827, P=0.000). The incidence of cerebral infarction in moderate-risk group (ABCD3≥4points) and moderate group(artery stenosis≥50%)were significantly higher than that in low-risk group (ABCD3≥3points) and vascular mild group(artery stenosis<50%) (P<0.001).To predict risks of early cerebral infarction in TIA patients within 7 days, the AUC of ABCD3 and intra-and extra-cranial artery stenosis were 0.752 and 0.779 (P<0.001), respectively. ConclusionsABCD3 score is effective to predict risk of cerebral infarction after TIA within 7 days, and the predictive accuracy can be improved by combination of ABCD3 score and the finds of CTA.