Objective To investigate the effect of an optimized tube fixation method on the tube fixation failure rate in stroke patients with concurrent nasogastric and oxygen tubes using an interrupted time series analysis. Methods A total of 1 655 stroke patients with concurrent nasogastric and oxygen tubes admitted to the Department of Neurology of a hospital from July 2021 to June 2025 were enrolled. July 2023 was set as the intervention time point. Before the intervention (July 2021 to June 2023), the conventional adhesive tape fixation method was used; after the intervention (July 2023 to June 2025), the optimized tube fixation method was adopted. An interrupted time series segmented regression model was used to analyze the monthly changes in tube fixation failure rate before and after the intervention. Results The pre-intervention baseline level of tube fixation failure rate was 33.763%. After the implementation of the intervention, the failure rate exhibited an immediate and significant reduction, with a level change of −13.692% (95% CI: −17.711 to −9.673, P<0.001). The post-intervention slope change was −0.254% (P=0.292). Although a mild declining trend was observed, the change in slope was not statistically significant. The actual post-intervention slope indicated a monthly reduction of 0.159%, and the failure rate remained stably at a low plateau of approximately 20%. Conclusion The optimized tube fixation method can markedly reduce the incidence of tube fixation failure in stroke patients receiving double-tube indwelling, with a prominent immediate effect. The lack of statistical significance in the long-term trend after intervention is mainly attributed to the floor effect, as the failure rate had already decreased to a low level. This finding suggests that the intervention maintains satisfactory efficacy with limited room for further improvement, rather than loss of effectiveness. 

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