Objective To evaluate the effectiveness of vascular access maintenance training centered on the group standard Specification for Establishment and Maintenance of Vascular Access in Non‑Bioartificial Liver Support (T/GXAS 487—2023) using the Kirkpatrick model, and to provide evidence for the clinical translation of specialized nursing standards. Methods A total of 38 intensive care unit nurses from a class A tertiary hospital in Nanning were selected as training participants. A vascular access maintenance training program was developed with the group standard Specification for Establishment and Maintenance of Vascular Access in Non‑Bioartificial Liver Support (T/GXAS 487—2023) as the core, and it was delivered through a combined teaching model of "theoretical lectures + scenario‑based simulation + group discussion." The training effectiveness was evaluated based on the Kirkpatrick model: at the reaction level, participating nurses' satisfaction rate with the training; at the learning level, participating nurses' nursing attitudes and theoretical knowledge before and after training; at the behavior level, participating nurses' nursing practices before and after training; and at the results level, the incidence of vascular access‑related complications and satisfaction rates of patients cared for by the participating nurses before (Group A, 30 cases) and after (Group B, 30 cases) the training. Results The participating nurses' satisfaction rates with the teaching content, modes, and environment were 97.37%, 94.74%, and 92.11%, respectively. After training, the participating nurses achieved significantly higher scores in nursing attitude and theoretical knowledge examinations than before the training (all P<0.05); the behavioral scores for five items—routine maintenance, catheter flushing and locking techniques, dressing changes and puncture site protection, complication prevention and management, and extubation indications and management—were all better than before (all P<0.05). The total incidence of vascular access‑related complications in Group B (6.67%) was lower than that in Group A (33.33%) (P<0.05), and the satisfaction rate with vascular access maintenance in Group B (96.67%) was higher than that in Group A (83.33%), but the difference was not statistically significant. Conclusion The Kirkpatrick model-based evaluation confirms that the vascular access maintenance training centered on the group standard Specification for Establishment and Maintenance of Vascular Access in Non‑Bioartificial Liver Support (T/GXAS 487—2023) can effectively enhance nurses' professional competence and standard implementation ability, achieving the translation from "knowledge acquisition" to "behavioral improvement" and ultimately to "patient benefit", with significant clinical application value.

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