内科

目的探讨颅脑外伤患者血清CK-MB的变化与病情及预后的相关性。方法把80例住院患者分为两组，按GCS 3～8分32例为重型组，GCS 9～15分48例为轻中型组；于伤后监测血清CK-MB。以健康体检者30例为对照组。按GOS评分为预后良好组、预后差组和死亡组，观察CK-MB与预后的关系。结果（1）轻中型组、重型组24 h CK-MB与对照组比较，差异有统计学意义（P＜0.01）；轻中型组与重型组比较，差异也有统计学意义。（2）死亡组CK-MB与预后良好组比较，差异有统计学意义（P＜0.01）。结论CK-MB值越高，病情越重，预后越差。提示颅脑外伤患者血清CK-MB活性变化可作为判断病情及预后的参考指标。

ObjectiveTo investigate how the diversification of serum CK-MB relate to the clinical diagnosis and prognosis of patients with head injuries.Method80 patients were divided into two groups:32 patients were selected to be severe group(3≤GCS≤8);48 patients were selected to be light medium group(9≤GCS≤15) .Their serum CK-MB would be monitored after injured and those cases were divided into good prognosis group,poor prognosis group and death group by GOS score for observing the relationship of CK-MB and prognosis.The control group is composed of 30 healthy people.Results(1)The statistics of CK-MB in 24h of the severe group and the light medium group were compared to that of the control group.The differences among the three groups were significant (P＜0.01). And the light medium group was compared with severe group,the differences was statically significant (P＜0.01).(2) The difference of CK-MB between Death Group and Good-Prognosis Group was significant(P＜0.01).ConclusionsAs a result,higher CK-MB reflects that the patient’s clinical condition is more severe, and the prognosis is worse.The change of active serum CK-MB can be a reference to the clinical diagnosis and prognosis of patients with head injuries.

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