Objective To explore the clinical efficacy of fire dragon cupping therapy based on Biao-ben Gen-jie theory in treating vertigo of qi and blood deficiency pattern. Methods A total of 80 patients with vertigo of qi and blood deficiency pattern were selected as study subjects and divided into a control group or an observation group using a random number table, with 40 cases in each group. The control group received conventional treatment, while the observation group received additional fire dragon cupping therapy based on Biao-ben Gen-jie theory. The Dizziness Handicap Inventory (DHI) score and traditional Chinese medicine (TCM) syndrome score before and after 1 week of treatment, as well as the total effective rate after treatment, were compared between the two groups. Results Before treatment, there was no statistically significant difference in DHI score or TCM syndrome score between the two groups (all P>0.05). After 1 week of treatment, both groups showed decreased DHI scores and TCM syndrome scores compared to before treatment (all P<0.05), and the observation group had lower aforementioned scores than the control group (all P<0.05); the total effective rate in the observation group was higher than that in the control group (95.00% vs 70.00%) (P<0.05). Conclusions Fire dragon cupping therapy based on Biao-ben Gen-jie theory is effective in treating vertigo of qi and blood deficiency pattern and can significantly improve patients' vertigo symptoms.