Objective To explore the effect of cold snare polypectomy (CSP) in the treatment of 6-15 mm gastric polyps. Methods A total of 100 patients with 6-15 mm gastric polyps admitted to Tiankang Hospital of Tianchang City, Anhui Province, from March 2022 to July 2024 were randomly divided into two groups: 50 cases in the observation group were treated with CSP for gastric polyps, 50 cases in the control group were treated with endoscopic mucosal resection (EMR) for gastric polyps. The complete resection rate of polyps, intraoperative bleeding rate, Visual Analog Scale (VAS) score for pain assessment at postoperative awakening, operation time for polyps excision, hospital stay, hospitalization cost, and incidence of postoperative complications were compared between the two groups. Results There was no statistically significant difference in the complete resection rate of polyps or the incidence of postoperative complications between the observation group and the control group (all P>0.05). The intraoperative bleeding rate in the observation group was higher than that in the control group, but the VAS score for pain at postoperative awakening was lower than that in the control group, the operation time for polyps excision and hospital stay were shorter than those in the control group, and the hospitalization cost was lower than that in the control group (all P<0.05). Conclusion In the treatment of 6-15 mm gastric polyps, CSP has the advantages of shorter operation time for polyps excision and hospital stay, lower hospitalization cost, milder pain at postoperative awakening, lower requirements for operators' technical skills, and high surgical safety.