Objective To explore the effects of intermittent fasting on glucose and lipid metabolism and body weight in overweight/obese patients with type 2 diabetes mellitus. Methods A total of 140 overweight/obese patients with type 2 diabetes mellitus were selected as research subjects and randomly divided into a control group or a study group, with 70 cases in each group. Patients in the control group received conventional treatment and nursing, on the basis of which patients in the study group received an additional intermittent fasting intervention, and both groups received a continuous 12 week-intervention. The glucose metabolism indicators (fasting blood glucose, 2-hour postprandial blood glucose, and glycosylated hemoglobin [HbA1c]), lipid metabolism indicators (total cholesterol [TC], triglycerides [TG], low-density lipoprotein cholesterol [LDL-C], and high-density lipoprotein cholesterol [HDL-C]), body weight, and body mass index (BMI) before and after intervention, as well as the incidence of adverse events during intervention, were compared between the two groups. Results After 12 weeks of intervention, fasting blood glucose, 2-hour postprandial blood glucose, HbA1c, TC, TG, LDL-C, body weight, and BMI in the study group were lower than those before intervention, and the above in the study group were lower than those in the control group (all P<0.05); the HDL-C level in the study group was higher than that before intervention, and it was higher than that in the control group (all P<0.05). There was no statistically significant difference in the total incidence of adverse events between the two groups during the intervention period (P>0.05). Conclusion Under professional medical supervision, intermittent fasting can effectively control blood glucose levels, improve glucose and lipid metabolism, and reduce body weight in overweight/obese patients with type 2 diabetes mellitus, suggesting it could be a relatively safe dietary intervention strategy.

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