Objective To understand AIDS patients' mental health status and to explore the correlations between degree of internet addiction and tendencies of aggressive behaviors in AIDS patients. Methods A total of 600 AIDS patients who were treated in an infectious diseases clinic of a hospital in Nanning, Guangxi, from 2020 to 2021 were selected as the research subjects. The face-to-face semi-structured interviews were conducted with the self-developed mental health interview outline, the Grounded Theory, a research method, was used for data analysis, and questionnaires containing the Internet Addiction Test and the Buss-Perry Aggression Questionnaire (BPAQ) were handed out to 287 patients. The total BPAQ scores were compared between patients with different demographic characteristics, and Pearson correlation analysis was used to explore the correlations between degree of internet addiction and tendencies of aggressive behaviors in AIDS patients, multivariate linear regression analysis was used to evaluate the predictive effect of degrees of internet addiction on aggressive behaviors. Results AIDS patients had different degrees of negative emotional distress, including loneliness, depression, anxiety, fear, breakdown, and regret, as well as feelings of discrimination, suicidal behavior, and interpersonal withdrawal. There were statistically significant differences in the total scores of BPAQ between AIDS patients of different ages and between those with different education levels (all P<0.05). The degree of internet addiction was positively correlated with the total score and the dimensional scores of BPAQ in AIDS patients (all P<0.05). The degree of internet addiction had positive predictive effects on aggressive behavior and its multiple dimensions in AIDS patients (all P<0.05), and the degree of internet addiction could predict an 18.6% variation in aggressive behavior. Conclusion The mental health status of AIDS patients is not optimistic, there are differences in the aggressive behavior tendency between patients of different ages and those with different education levels; the degree of internet addiction is positively correlated with the tendency of aggressive behavior and have a positive predictive effect on the aggressive behavior tendency. To better improve AIDS patients' treatment compliance and life satisfaction and maintain social stability and peace, attention should be paid to their mental health issues and other related behaviors.