Objective To investigate the effects of structured aerobic exercise combined with resistance exercise on blood glucose and pregnancy outcomes in patients with gestational diabetes mellitus (GDM). Methods A total of 84 patients with GDM were selected as the study subjects and were randomly divided into a control group or an observation group, with 42 cases in each group. The control group was given normal guidance on exercise during pregnancy, based on which the observation group was given guidance on structured aerobic exercise combined with resistance exercise. Fasting blood glucose (FBG) and 2-hour postprandial blood glucose (2h PBG) before and 6 weeks after the intervention, as well as adverse pregnancy outcomes, were compared between the two groups. Results With 4 patients withdrawing from the study, there were 39 cases in the control group and 41 cases in the observation group in the end. Before the intervention, there was no statistically significant difference in the level of FBG or 2h PBG between the two groups (all P>0.05). After 6 weeks of the intervention, the levels of FBG and 2h PBG in the observation group were lower than those in the control group (all P<0.05). The incidence of cesarean section in the observation group was lower than that in the control group (P<0.05), but there was no statistically significant difference in the incidence of preterm birth, macrosomia, postpartum hemorrhage, or neonatal asphyxia between the two groups (all P>0.05). Conclusion Structured aerobic exercise combined with resistance exercise helps improve blood glucose levels and reduce the risk of cesarean section in patients with GDM.