Objective To investigate the effects of modified Guizhi Fuling Pills combined with danazol on the myoma volume and the sex hormone levels in patients with uterine myoma (UM). Methods A total of 97 UM patients were selected as the study subjects and were divided into a control group (n=48) or an observation group (n=49) by the random number table method. The control group was treated with danazol, based on which the observation group was treated with modified Guizhi Fuling Pills additionally, and both groups were treated for 3 menstrual cycles. The clinical efficacy; myoma volume and serum levels of sex hormones, transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 before and after treatment; and adverse reactions during treatment were compared between the two groups. Results After being treated for 3 menstrual cycles, the total effective rate of the observation group (93.88%) was higher than that of the control group (79.17%)(P<0.05); the myoma volumes in both groups were smaller than those before treatment, and the myoma volume was smaller in the observation group than in the control group's (all P<0.05); the serum levels of follicle-stimulating hormone, estradiol, luteinizing hormone, TGF-β1, VEGF, and MMP-9 in the two groups were lower than those before treatment, and the levels of the abovementioned indicators in the observation group were lower than those in the control group (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment (P>0.05). Conclusion Modified Guizhi Fuling Pills combined with danazol has a definite effect in the treatment of UM, which can shrink the myoma volume, regulate the secretion of sex hormones, and lower the serum levels of TGF-β1, VEGF, and MMP-9, with good safety.

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