Objective To investigate the application effect of the Internet + Information-Motivation-Behavioral Skills (IMB) model in the whole-process care of patients undergoing radiotherapy for nasopharyngeal carcinoma. Methods A total of 100 patients undergoing radiotherapy for nasopharyngeal carcinoma were selected as the research subjects and randomly divided into a control group or an observation group, with 50 cases in each group; after excluding those who lost to follow-up, 49 patients were included in the control group and 48 patients in the observation group in the end. The control group received a routine nursing intervention, based on which the observation group received Internet + IMB model-based whole-process care, and both groups were intervened from the time in which the doctor issued the hospitalization certificate to 6 months after discharge. The self-care ability and severity of toxic and side effects of radiotherapy before radiotherapy, after 30 radiotherapy treatments, 3 months after discharge, and 6 months after discharge were compared between the two groups. Results Before radiotherapy, there was no statistically significant difference in each dimension score or the total score of the Exercise of Self-care Agency Scale (ESCAS), as well as the severity of dry mouth, nasal obstruction, or mouth opening difficulty, between the two groups (all P>0.05). Each dimension score and the total score of ESCAS in the observation group were higher than those in the control group after 30 radiotherapy treatments, 3 months after discharge, and 6 months after discharge (all P<0.05); the severity of dry mouth and nasal obstruction in the observation group after 30 radiotherapy treatments, 3 months after discharge, and 6 months after discharge, as well as the severity of mouth opening difficulty in the observation group 6 months after discharge, were milder than those in the control group (all P<0.05). Conclusion The application of the Internet + IMB model in the whole-process care of patients undergoing radiotherapy for nasopharyngeal carcinoma is conducive to improving self-care ability and reducing the severity of toxic and side effects of radiotherapy.