Objective To investigate the correlations between Helicobacter pylori (H. pylori) infection and metabolic indicators such as blood lipids and uric acid (UA) in a healthy physical examination population. Methods A total of 1,093 healthy individuals undergoing physical examinations were enrolled as research subjects and divided into an H. pylori-positive group or an H. pylori-negative group according to the H. pylori infection. General data (e.g., sex, age) and levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), α-L-fucosidase (AFU), total bilirubin (T-BiL), total bile acid (TBA), UA, and blood urea nitrogen (BUN) were compared between the two groups; logistic regression analysis was used to identify risk factors for H. pylori infection. Results Among the 1,093 healthy individuals undergoing physical examinations, 258 were H. pylori-positive, showing an infection rate of 23.60%. The H. pylori-positive group had a higher proportion of females, greater age, and elevated levels of TC and LDL-C compared with the H. pylori-negative group (all P<0.05). No statistically significant difference was observed in BMI or level of UA, BUN, TG, AFU, T-BiL, or TBA between the two groups (all P>0.05). Logistic regression analysis identified age and gender as independent risk factors for H. pylori infection (all P<0.05). Conclusion H. pylori infection is correlated with gender and age. While H. pylori infection influences lipid metabolism, it has no effect on UA, T-BiL, or TBA metabolism.

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