内科

目的探讨苯扎贝特配合藻酸双酯钠治疗急性高脂血症性胰腺炎（AHP）的疗效。方法将63例AHP患者分为观察组（n=33）和对照组（n=30），对照组用常规方法治疗，包括禁食、持续胃肠减压、抗生素预防感染、静滴质子泵抑制剂、使用生长抑素类药物抑制胰腺外分泌、甲磺酸加贝酯抑制胰酶活性，丹参注射液改善胰腺微循环、抗休克并维持水电解质酸碱平衡支持对症治疗。观察组在常规方法治疗的基础上，用苯扎贝特鼻肠管内饲入配合静脉滴注藻酸双酯钠治疗，比较两组的疗效。结果观察组患者C反应蛋白（CRP）、血尿淀粉酶恢复正常时间，均短于对照组，差异有统计学意义（P＜0.05）；并发症发生率、重症胰腺炎发生率、手术中转率、病死率均少于对照组（P＜0.05）；血清钙、72 h血清甘油三酯下降幅度则高于对照组（P＜0.05）。结论苯扎贝特配合藻酸双酯钠治疗AHP能迅速有效地降低患者血清甘油三酯浓度，能有效地缓解病情，改善预后。

To explore the efficacy of bezafibrate combined with propylene glycol alginate sodium in the treatment of acute hyperlipidemic pancreatitis (AHP).Methods63 AHP patients were divided into observation group(n=33) and control group(n=30).Conventional treatment,including abrosia,gastrointestinal decompression,application of antibiotics and proton pump inhibitors, somatostatin,Gabexate mesylate,and so on,were undergo in control group.On the basic therapy of control group,bezafibrate(nasal feeding) and propylene glycol alginate sodium(intravenous drip) were added in observation group.The efficacy of the two groups was compared after treatment.ResultsRecovery time of CRP,blood and urine amylase of observation group was significantly shorter than control group(P＜0. 05),rate of complications,severe pancreatitis,transformation to operation and fatality were lower than control group′s(P＜0. 05);but serum calcium and the descend range of serum triglyceride in 72h were higher than control group(P＜0.05).ConclusionsBezafibrate combined with propylene glycol alginate sodium can lower serum triglyceride levels,relieving conditions of illness,improving the prognosis of diseases.