内科

目的观察稳定性冠心病合并不同糖代谢患者的8-羟基脱氧鸟苷（8-OHdG）水平并探讨其临床意义。方法采用口服75 g葡萄糖耐量试验（OGTT）将77例稳定性冠心病患者分为正常糖耐量（NGT）组26例、单纯糖耐量异常（IGT）组26例和2型糖尿病（T2DM）组28例，同时选择23例健康体检者为健康对照（NC）组，用ELISA方法测定所有入选者血8-OHdG 的含量。结果血8-OHdG含量在T2DM组为（4.5±0.7）ng/ml，IGT组为（3.8±0.9）ng/ml，NGT组为（3.4±0.5）ng/ml，均较健康对照组（2.9±0.7）ng/ml明显升高（P＜0.05），且与胰岛素抵抗指数（HOMA-IR）和糖化血红蛋白（HbA1c）呈正相关。结论血8-OHdG水平反映了氧化应激，可能对稳定性冠心病合并糖尿病有预测价值。

ObjectiveTo observed the level of serum 8-hydroxy-Guanine(8-OHdG) in patients with stable coronary heart disease combined with different stage of glucose metabolism.Methods80 patients with stable coronary heart disease were divided into normal glucose tolerance group(NGT group,n=23),impaired glucose tolerance group(IGT group,n=26) and type 2 diabetes mellitus group(T2DM group,n=28),according to the result of oral glucose tolerance test(OGTT).At the same time,23 health adults were recruited as normal control group(NC).Serum 8-OHdG of all the selected people were measured with ELISA method.ResultsThe concentration of serum 8-OHdG in T2DM group was (4.5±0.7) ng/ml,IGT group (3.8±0.9)ng/ml;NGT group (3.4±0.5) ng/ml.They were both significantly higher than that of the NC group［(2.9±0.7) ng/ml］.Furthermore,there was a positive correlation between the levels of serum 8-OHdG and HOMA-IR and HbA1c in patients with stable coronary heart disease.ConclusionsSerum 8-OHdG level can reflect the stage of oxidative stress and may be used as an indicator for stable coronary heart disease patients combined with diabetes mellitus.

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