Objective To explore the application effect of a dual-driver support model integrating on-demand intravenous therapy nursing training and synchronized homogenized cyclical tracking based on the ADDIE model. Methods A total of 1,788 nurses engaged in intravenous therapy-related work from 15 medical institutions (including 1 tertiary hospital, together with 7 affiliated secondary hospitals and 7 primary-level health centers) were selected as research subjects. The core competencies in intravenous therapy (scores of the Nurses' Core Competence Assessment Scale for Intravenous Therapy), the use of infusion devices (steel needles, indwelling needle, peripherally inserted central catheters [PICC], central venous catheters [CVC], totally implantable venous access ports [TIVAP]), and nursing quality (non-standard maintenance rates of peripheral venous catheters [indwelling needle] and central venous access devices [PICC, CVC, TIVAP], as well as incidences of complications associated to peripheral venous catheters and central venous access devices) were compared among medical institutions at all levels before the support and 18 months after the support. Results Compared with before the support, 18 months after the support, the scores of the Nurses' Core Competence Assessment Scale for Intravenous Therapy of nurses in medical institutions at all levels increased (all P<0.05); in the tertiary hospital, the utilization rate of steel needles decreased and the utilization rate of CVC increased, while in primary medical institutions (secondary hospitals and primary-level health centers), the utilization rate of steel needles decreased and the utilization rate of indwelling needles increased (all P<0.05); the non-standard maintenance rates of peripheral venous catheters and central venous access devices in both tertiary hospitals and primary medical institutions decreased (all P<0.05); there was no statistically significant difference in the incidence of complications associated to peripheral venous catheters and central venous access devices in the tertiary hospital (all P>0.05), while the incidence of complications associated to peripheral venous catheters and central venous access devices in primary medical institutions decreased (all P<0.05). Conclusion The dual-driver support model integrating on-demand intravenous therapy nursing training and synchronized homogenized cyclical tracking based on the ADDIE model can effectively improve the core intravenous therapy competence of nurses in a tightly integrated medical alliance, optimize the selection of infusion devices, and significantly enhance the quality of intravenous therapy nursing.