Objective To explore the implementation effectiveness of localized clinical pathway management under the diagnosis-related groups (DRG) payment model for patients with tubal pregnancy, premature rupture of membranes, and indirect inguinal hernia. Methods Patients with tubal pregnancy (800 cases), premature rupture of membranes (540 cases), and indirect inguinal hernia (760 cases) admitted to Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital from January 2023 to August 2024 were selected as the study subjects, and patients with each disease were randomly divided into an observation group or a control group. The observation group received localized clinical pathway management under the DRG payment model, while the control group received conventional diagnosis and treatment management. Treatment efficiency indicators (length of hospital stay), economic cost indicators (total hospitalization costs, material costs, medical service fees, examination and test fees, medication costs), patient experience indicators (patient satisfaction), and clinical safety indicators (incidence of complications) were compared between the two groups. Results Across all three disease entities, the observation group had less hospitalization days, lower total hospitalization costs, and lower medical service fees compared to the control group, while patient satisfaction was higher in the observation group than in the control group (all P<0.05); there was no statistically significant difference in material costs or the incidence of complications between the two groups (all P>0.05). For two disease entities, tubal pregnancy and indirect inguinal hernia, examination and test fees were lower in the observation group than in the control group (all P<0.05). For two disease entities, premature rupture of membranes and indirect inguinal hernia, medication costs were lower in the observation group than in the control group (all P<0.05). Conclusion Under the DRG payment model, implementing localized clinical pathway management can effectively shorten hospital stays, reduce medical costs, and improve patient satisfaction without increasing the risk of complications. This approach contributes to the synergistic optimization of medical quality, efficiency, cost, and patient experience.