Objective To explore the application effect of a standardized home-based tube care program in stroke patients discharged with indwelling tubes. Methods Through convenience sampling method, 74 stroke patients discharged with indwelling tubes between January and December 2024 were enrolled as research subjects, and they were randomly divided into an observation group or a control group by the random number table method, with 37 cases in each group. The control group received routine care, based on which the observation group was given a standardized home-based tube care program. Quality of life (36-Item Short Form Health Survey [SF-36] score) and self-care ability (Chinese version of the Exercise of Self-Care Agency Scale [ESCAS] score) were compared between the two groups before intervention and at 14 days and 28 days after discharge. Patients were further stratified by the type of indwelling tube at discharge, and tube-related adverse events within 28 days after discharge were compared between the two groups for patients with the same type of tube. Results Before intervention, there was no statistically significant difference in the SF-36 total score or the Chinese version of ESCAS total score between the two groups (all P>0.05); at 14 and 28 days after discharge, the SF-36 total score and Chinese version of ESCAS total score in the observation group were higher than those in the control group (all P<0.05). Within 28 days after discharge, the total incidence of urinary catheter-related adverse events in patients discharged with indwelling urinary catheters and the total incidence of gastric tube-related adverse events in patients discharged with indwelling gastric tubes were lower in the observation group than in the control group (all P<0.05). Conclusion Implementation of a standardized home-based tube care program can effectively improve quality of life and self-care ability, and reduce the incidence of tube-related adverse events in stroke patients discharged with indwelling tubes. 

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