Objective To investigate the current status of hypertension treatment adherence and analyze its influencing factors in elderly patients with human immunodeficiency virus (HIV) infection and hypertension. Methods A cross-sectional study design was employed, in which 495 elderly patients with HIV infection and hypertension were selected as the study subjects. A self-designed questionnaire and the therapeutic adherence scale for hypertensive patients (TASHP) were used for the survey. Multivariate logistic regression model was used to analyze the influencing factors of hypertension treatment adherence in this population. Results After excluding cases with incomplete data, 486 patients were finally included, among whom, 269 patients (55.35%) had poor hypertension treatment adherence. Multivariate logistic regression analysis showed that smoking (OR=2.298, 95% CI: 1.246-4.238, P<0.01) and alcohol consumption (OR=3.683, 95% CI: 1.875-7.235, P<0.01) were independent risk factors for poor hypertension treatment adherence in elderly patients with HIV infection and hypertension. Conclusion The current status of hypertension treatment adherence is severe among elderly patients with HIV infection and hypertension, with more than half showing poor adherence. Smoking and alcohol consumption are independent risk factors for poor hypertension treatment adherence in this population.