Objective To explore the effect of endoscopic mucosal resection (EMR) combined with metal clip closure on bleeding risk, gastrointestinal function, and safety in patients with colorectal polyps. Methods A retrospective study was conducted, in which a total of 108 patients with colorectal polyps admitted to Jingjiang Hospital of Traditional Chinese Medicine from July 2023 to July 2024 were selected as the research objects, and according to the treatment method, they were divided into the control group (54 cases, treated with simple EMR) or the observation group (54 cases, treated with EMR combined with metal clip closure). The perioperative basic indicators (operation time, intraoperative blood loss, hospital stay), postoperative recovery indicators (gastrointestinal function recovery indicators such as postoperative bowel sound recovery time, first flatus time, first defecation time, and Visual Analogue Scale [VAS] score for pain), and postoperative safety indicators (outcomes within 1 month after surgery such as delayed bleeding, secondary endoscopic hemostasis, and need for blood transfusion therapy, as well as the occurrence of other complications) were compared between the two groups. Results There was no statistically significant difference in operation time or hospital stay between the two groups (all P>0.05), and the intraoperative blood loss in the observation group was less than that in the control group (P<0.05). There was no statistically significant difference in postoperative bowel sound recovery time, first flatus time, first defecation time, or postoperative pain VAS score between the two groups (all P>0.05). Within 1 month after surgery, the incidence of delayed bleeding and the proportion of patients requiring secondary endoscopic hemostasis in the observation group were lower than those in the control group (all P<0.05); there was no statistically significant difference in the proportion of patients requiring blood transfusion therapy or the total incidence of other postoperative complications between the two groups (all P>0.05). Conclusion EMR combined with metal clip closure can effectively reduce intraoperative blood loss and the risk of delayed bleeding in patients with colorectal polyps, without affecting the recovery of postoperative gastrointestinal function or significantly increasing the risk of complications, and has good clinical application safety.

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