Objective To investigate the clinical effect of Callicarpa nudiflora granules in the treatment of cirrhotic portal hypertensive gastropathy. Methods A total of 60 patients diagnosed with cirrhotic PHG were enrolled as research subjects and randomly divided into a control group or an observation group, with 30 patients in each group. The control group received conventional symptomatic treatment including oral propranolol hydrochloride tablets and esomeprazole magnesium enteric-coated tablets, based on which the observation group was additionally treated with Callicarpa nudiflora granules, and both groups were treated continuously for 2 courses (6 months in total). The endoscopic efficacy, histopathological changes of the gastric mucosa, liver function indicators (alanine aminotransferase [ALT], aspartate aminotransferase [AST]), and comprehensive clinical efficacy were compared between the two groups. Results After 6 months of treatment, the total endoscopic effective rate of the observation group was 93.33% (28/30), which was higher than the 63.33% (19/30) of the control group, with a statistically significant difference (P<0.05); in the observation group, endoscopic mucosal hyperemia, edema, and mosaic-like lesions were significantly alleviated, and pathological changes such as gastric mucosal erosion and bleeding were improved compared with those before treatment and those in the control group. After 6 months of treatment, the serum levels of ALT and AST in the observation group were lower than those in the control group (all P<0.05). After 6 months of treatment, the total clinical effective rate of the observation group was 93.33% (28/30), which was higher than the 70.00% (21/30) of the control group, with a statistically significant difference (P<0.05). Conclusion Callicarpa nudiflora granules can effectively improve gastric mucosal lesions in patients with cirrhotic PHG, promote mucosal repair, and synergistically improve liver function, with significant clinical efficacy.

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